Protection against Radiation Leukemogenesis by Repeated Injections of Immune and INonimmune Foreign
نویسندگان
چکیده
Significant inhibition of lymphoid tumor development was observed in X-irradiated strain C57BL mice treated with multiple injections of rat antiserum prepared by im munization of Wistar-Furth or (Wistar-Furth-BN) F, rats with histocompatible lymphomas induced by the radiation leukemia virus (RadLV). However, there was also signifi cant inhibition, relative to phosphate-buffered saline con trols, in C57BL mice that received injections of normal rat serum. This prompted additional experiments in which fetal calf serum or Freund's complete adjuvant were in
منابع مشابه
Protection against radiation leukemogenesis by repeated injections of immune and nonimmune foreign sera.
Significant inhibition of lymphoid tumor development was observed in X-irradiated strain C57BL mice treated with multiple injections of rat antiserum prepared by im munization of Wistar-Furth or (Wistar-Furth-BN) F, rats with histocompatible lymphomas induced by the radiation leukemia virus (RadLV). However, there was also signifi cant inhibition, relative to phosphate-buffered saline con trols...
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FTER THE DISCOVERY that injection of syngeneic ( isologous ) bone marrow or spleen cells can antagonize both the acute lethal effectsl,2,a and the late leukemogenic effects4’5 of total body x-irradiation in mice, attempts to determine the mechanisms involved led to some conflicting conclusions.#{176}’7’8’9’10”1 As far as the acute lethal action of a single high dose of total body x-irradiation ...
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